Transformative Technologies in Pancreatic Cancer
In recognition of Pancreatic Cancer Awareness Month, cutting-edge technologies are transforming our understanding of pancreatic ductal adenocarcinoma (PDAC).
From Organoids to Insight
Presented by Dr. Max Reichert, this topic explores pancreatic ductal adenocarcinoma (PDAC) and its extensive cellular heterogeneity, underlying its aggressive clinical behavior and resistance to therapy.
PDAC exhibits extensive cellular heterogeneity, which underlies its aggressive clinical behavior and resistance to therapy.
Decoding Plasticity and Heterogeneity in Pancreatic Cancer
A collagen-embedded, branching organoid model has been developed to mirror the hierarchical organization and phenotypic complexity observed in human and murine PDAC.
- The system reveals that tumor cell states in PDAC are not randomly distributed.
- Tumor cell states emerge through self-organizing programs governed by epithelial–mesenchymal plasticity.
Author's summary: Cutting-edge technologies transform understanding of PDAC.
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